How STDs Increase The Risk Of Becoming Infected With HIV

�Individuals world Health Organization have a sexually hereditary disease (e.g., venereal herpes, gonorrhoea, syphilis, and chlamydia) and women with yeast and bacterial vaginal infections get an increased risk of becoming septic with HIV if uncovered to the virus through sexual contact lens. Although several explanations deliver been proposed, exactly how and why STDs accept this effect has non been unclutter. Now, Teunis B.H. Geijtenbeek and colleagues, at VU University Medical Center, The Netherlands, have described a way in which STDs can increase acquisition of HIV-1 infection in an ex vivo human cutis explant model that they hope power be amenable to curative modulation to prevent HIV transmission.



In the ex vivo human skin explant model, although immature immune cells known as Langerhans cells (LCs) captured HIV, they did non efficiently air the virus to T cells, something that is essential for the innovation of full disease. By contrast, effective virus transmitting was ascertained if LCs were activated by inflammatory stimuli. As the infectious agents that cause the STDs thrush and gonorrhea triggered the same inflammatory stimuli in vaginal and skin explants, the authors suggest that in the presence of an STD-causing infectious agent, LCs power become activated, thereby increasing an individual's risk of becoming infected with HIV. Further, these data paint a picture that antiinflammatory therapies mightiness provide a way to prevent HIV transmission.





TITLE: TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmittance by human Langerhans cells ex vivo



AUTHOR CONTACT:

Teunis B.H. Geijtenbeek

VU University Medical Center, Amsterdam, The Netherlands.



View the PDF of this article at: http://www.jci.org/



Source: Karen Honey

http://www.jci.org/



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