How STDs Increase The Risk Of Becoming Infected With HIV

�Individuals world Health Organization have a sexually hereditary disease (e.g., venereal herpes, gonorrhoea, syphilis, and chlamydia) and women with yeast and bacterial vaginal infections get an increased risk of becoming septic with HIV if uncovered to the virus through sexual contact lens. Although several explanations deliver been proposed, exactly how and why STDs accept this effect has non been unclutter. Now, Teunis B.H. Geijtenbeek and colleagues, at VU University Medical Center, The Netherlands, have described a way in which STDs can increase acquisition of HIV-1 infection in an ex vivo human cutis explant model that they hope power be amenable to curative modulation to prevent HIV transmission.



In the ex vivo human skin explant model, although immature immune cells known as Langerhans cells (LCs) captured HIV, they did non efficiently air the virus to T cells, something that is essential for the innovation of full disease. By contrast, effective virus transmitting was ascertained if LCs were activated by inflammatory stimuli. As the infectious agents that cause the STDs thrush and gonorrhea triggered the same inflammatory stimuli in vaginal and skin explants, the authors suggest that in the presence of an STD-causing infectious agent, LCs power become activated, thereby increasing an individual's risk of becoming infected with HIV. Further, these data paint a picture that antiinflammatory therapies mightiness provide a way to prevent HIV transmission.





TITLE: TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmittance by human Langerhans cells ex vivo



AUTHOR CONTACT:

Teunis B.H. Geijtenbeek

VU University Medical Center, Amsterdam, The Netherlands.



View the PDF of this article at: http://www.jci.org/



Source: Karen Honey

http://www.jci.org/



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Cutting those Apron Strings

Apron Strings is the debut feature film of Sima Urale and looks at the changing face of South Auckland through the eyes of two selfsame different families.

The movie was made for $2 million and filmed on location in Auckland in October and November last year.

Producer Rachel Gardner describes the film as "a little kiwi motion-picture show made for not very much money by a bunch of women."

The original concept for the plastic film was conceived by writers Shuchi Kothari and Dianne Taylor over a bowl of noodles in London, and nutrient remains a recurring melodic theme throughout the film.

"Food is a metaphor for mothering and suffocating. All of the women in the film parent their loved ones through food, in very different ways - the bar house, the curry house and the television chef."

The low budget nature of the production meant that from the very beginning the filmmakers were forced to probe how every single cent could be best spent.

"Sima (Urale) and I went through every scene talking about where we could compromise, location changes or where we could fit a scenery into that day, keeping actors out of whatsoever or putt them in, just never-ending changes with the docket to try to have it fit."

Gardner said that making a low budget film is always departure to be a challenge.

"With low budget films there's more of a chance they'll make less money. If you've got bigger budget films you feature bigger stars and audiences are attracted to them."

There might be no �big names' just Apron Strings has attracted a gifted cast with plenty of international experience.

Actress Laila Rouass who plays the television receiver chef has previously appeared in the UK series Footballers Wives and Hollyoaks and Actor Scott Wills has appeared in the features Stickmen and Perfect Creature.

"Sima got such with child performances out of everyone. The throw up loved her! They adore her!" Gardner said.

She credits the "astonishing synergy and communication" of the cast and crew with the success of the externalize, saying "in that respect was such great intuitive feeling on the shoot from everyone".

The photographic film opened the 48th International Film festival in Auckland, something Gardner says was a capital payoff for everyone involved.

"We purposely didn't have a cast and crew masking so that everyone would come to the one at the film fete and everyone did. So the gang had the opportunity to celebrate what they did."

A charity viewing of the film volition take shoes on Monday, before the film opens to general audiences on Thursday, with proceeds departure to the widow of Navtej Singh - the shopkeeper lately killed in an armed robbery in South Auckland.

"The positive multiculturalism in Apron Strings was a good opportunity to have a charity screening in South Auckland for the�people to recognise the positives in that community."

Gardner hopes the film will repeat the recent winner of Second Hand Wedding.

"It's about how the audience responds to it and you can't second suppose them, everything is subjective and some people will love it and some won't. It's great to evoke unassailable emotion either way."

* Apron Strings opens on August 14 across New Zealand.

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Patty Ryan

   
Artist: Patty Ryan

   Genre(s): 
Dance
   

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Discography:


   
 You're My Love, You're My Life '98 CD5

   Year: 1998   
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 Love Is The Name Of The Game

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Kiani, Majid

   
Artist: Kiani, Majid

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Discography:


   
 Haft Dastgahe CD3

   Year: 1992   
Tracks: 3

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Yale University honours Macca with Dr degree

Washington (ANI): Sir Paul McCartney has been awarded an honorary Doctor of Music degree from Yale University. As he walked on stage to accept the degree at the university's graduation ceremony, the band gave a fitting reception, playing 'Hey Jude'. Yale President Richard Levinhe hailed Macca for awakening a generation with his fresh take on "rock, roll, rhythm and blues" and for his charity works. "Here, there and everywhere, you have pushed the boundaries of the familiar to create new classics. We admire your musical genius and your generous support of worthy causes," E! Online quoted him, as saying. This is the second honour that the musician has received. He was knighted by the Queen of England in 1996, and took on the title of Sir Paul.

Gallows Pole

   
Artist: Gallows Pole

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Other
   

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 Exorcism

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Kodo

   
Artist: Kodo

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Ethnic
   Folk
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   Other
   

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 Mondo Head

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Tracks: 11


   
 Live at the Acropolis Athens Greece

   Year: 2000   
Tracks: 7


   
 Sai So

   Year: 1999   
Tracks: 10


   
 Ibuki

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Tracks: 10


   
 Irodori

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Tracks: 6


   
 The Hunted - Original Motion Picture Soundtrack

   Year: 1995   
Tracks: 15


   
 Live At Acropolis

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Tracks: 7


   
 Best Of KODO

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Tracks: 8


   
 Best Of

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Tracks: 8


   
 Blessing Of The Earth

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Tracks: 7


   
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 Tsutsumi

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 Blessing the Earth.

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Kodo is a Japanese grouping that has become an international phenomenon, based on the island of Sado, that has taken the universe by storm with their new stylings on semi-traditional taiko drumming. Founded in 1981, the group's key out has three-fold signification; according to the group, it translates both to "twinkling -- the primal source of all rhythm," and "children of the drum, a manifestation of Kodo's desire to play their drums only, with the heart of a child." The grouping spends one-third of an average year touring in Japan, third touring the rest of the creation, and one-third in rigorous workouts in their hamlet on Sado. They have toured in all continents demur Antarctica in their attempts to facing pages universe pacification via the messenger of music. Among their projects, aside from straightforward taiko performances, are a collaboration with raw eld synthesiser genius Isao Tomita for Nasca Fantasy, instructing the über-eclectic Cirque du Soleil in taiko for their have performances, the soundtrack for The Hunted, and a yearly "Earth Celebration" festival on Sado for percussionists from around the universe to pay heed. They ar ambassadors of peace through music and the current summit bearers of the living art form of taiko drumming.